I Am Sam (2000)

A mentally retarded man fights for custody of his 7-year-old daughter, and in the process teaches his cold-hearted lawyer the value of love and family.

Maze (2000)

An artist with Tourette's syndrome and an aversion to romance falls for his best friend's girl in this sometimes comic drama. Lyle Maze (Rob Morrow), a successful painter who's also starting to explore sculpture, relies on emotional armor a foot thick to protect him from other people. In addition to suffering from uncontrollable physical tics and loud outbursts, Lyle is also prone to obsessive-compulsive disorder. Afraid that his artistic gifts and his disease spring from the same well, he eschews the well-meaning advice of his doctor pal, Mike (Craig Sheffer), and refuses to try the new drug therapies available. He also rejects any attempt to fix him up with women. But when rebel-without-a-cause Mike decides to tilt at windmills in Africa for seven months as a member of Doctors Without Borders, Lyle finds himself in a precarious position. Callie (Laura Linney), Mike's acerbic ad-exec girlfriend, has confided to him that she's pregnant but unwilling to use her condition as leverage to shore up her troubled relationship. Soon, Lyle is coaching Callie through natural childbirth classes, playing surrogate father-to-be, and falling in love. Inspired by the documentary Twitch and Shout, Maze marked the first trip behind the camera for actor Rob Morrow, who played another man with Tourette's in the film Other Voices.

Misery (1990)

Misery is a 1990 American psychological horror/thriller film, based on Stephen King's 1987 novel of the same name. Directed by Rob Reiner, the film received critical acclaim for Kathy Bates' performance as the psychopathic Annie Wilkes

What's Eating Gilbert Grape (1993)

Swedish director Lasse Hallstrom's follow-up to the underrated Once Around earned far more attention than its predecessor thanks to the judicious casting of perennial thinking woman's heartthrob Johnny Depp and a certain up-and-coming thespian by the name of Leonardo DiCaprio. A prisoner of his dysfunctional family's broken dreams in tiny Endora, IA, Gilbert (Depp) serves as breadwinner and caretaker for his mother and siblings following his father's suicide and his older brother's defection. Momma (Darlene Cates) is a morbidly obese shut-in who hasn't left the house in seven years; her children include retarded Arnie (DiCaprio), who's about to turn 18 despite a host of negative medical forecasts, and terminally embarrassed Ellen (Mary Kate Schellhardt), who's emerging from an awkward adolescence. When he's not taking care of the difficult but tender Arnie, Gilbert spends his time fixing up the family's tattered farmhouse, working at a failing mom-and-pop grocery store and hanging with local misfits Bobby (Crispin Glover), an overly ambitious junior undertaker, and Tucker (John C. Reilly), a handyman who hankers after a job at the new burger franchise. Into this complicated but essentially unchanging social universe steps Becky (Juliette Lewis), a thoughtful young woman who's been escorting her nomadic grandmother from state to state in a mobile-home caravan. As Becky teaches Gilbert to finally consider his own happiness for a change, she disrupts both his family obligations and his long-running affair with a lonely housewife (Mary Steenburgen). Adapted by Peter Hedges from his own novel of the same name, What's Eating Gilbert Grape was the first and only film role for non-actress Cates, whom the filmmakers discovered on an episode of the Sally Jesse Raphael Show titled "Too Heavy to Leave Their House."

My Family's Secret

When JASON DARCIE (Dylan Neal), attempts suicide, he leaves a cryptic note for his wife LARA DARCIE (Nicholle Tom), suggesting that the death of his little sister years ago wasn't really an accident—and he may have even had a hand in it.

Driven by the need to know more about her husbands dark past and the secret that led him to want to end his life, Lara goes back to the small town where Jason was raised. There, she finds his father now senile and in a nursing home, leaving her with only Jasons younger brother GRADY (Philip Riccio) to help her unravel the mysterious confession in Justins note.

But what Lara doesnt know is that Grady suffers from Dissociative Identity Disorder (formerly known as Multiple Personality Disorder). Lara's probe into the brothers chilling childhood causes one of Gradys more aggressive personalities to take control, eager to protect his familys secret and willing to stop at nothing—even murder—to keep the past buried.

As Lara gets closer to the truth, she puts herself and another woman, CANDY (Cinthia Burke), an attractive but antisocial ex-con that Grady often confesses his problems to, in grave danger. Realizing that Gradys most twisted personality is in control and after them, Lara must save herself and Candy from suffering the same fate as Gradys sister

Sybil

Sybil is a 1973 book by Flora Rheta Schreiber about the treatment of Sybil Dorsett (a pseudonym for Shirley Ardell Mason) for dissociative identity disorder (then referred to as multiple personality disorder) by her psychoanalyst, Cornelia B. Wilbur.

The book was made into two movies of the same name, once in 1976 and again as a television movie in 2007. (Wikepedia)

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One Flew Over the Cuckoo's Nest (1975)

Jail is a frequent residence for McMurphy, whose latest conviction is for statutory rape. Rather than spending time behind bars, he decides it might be easier to serve his time in a psychiatric hospital, so he "plays mad." The plan works, but McMurphy soon discovers that life isn't so great in an asylum. The rules are looser, but some of the privileges he associated with prison - like being able to watch the World Series on TV - do not apply. Undaunted, McMurphy begins to make himself the most popular man in the ward, appealing to types as diverse as the diminutive, talkative Martini (Danny DeVito) and the tall deaf-mute American Indian, who is known as "The Chief" (Will Sampson). There to thwart McMurphy at every turn is Nurse Ratched, whose methods of treatment are so proscribed by rules and regulations that she can't see she's sometimes doing more harm than good.

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